Select Publications
Cancer prevalence across vertebrates
Compton, Z. T., Mellon, W., Harris, V. K., Rupp, S., Mallo, D., Kapsetaki, S. E., ... & Boddy, A. M. (2025). Cancer prevalence across vertebrates. Cancer discovery, 15(1), 227-244.
The evolutionary theory of cancer: challenges and potential solutions
Laplane, L., & Maley, C. C. (2024). The evolutionary theory of cancer: challenges and potential solutions. Nature Reviews Cancer, 24(10), 718-733.
Resistance Management for Cancer: Lessons from Farmers
Seyedi, S., Harris, V. K., Kapsetaki, S. E., Narayanan, S., Saha, D., Compton, Z., ... & Maley, C. C. (2024). Resistance Management for Cancer: Lessons from Farmers. Cancer research, 84(22), 3715-3727.
Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae)
Tollis, M., Robbins, J., Webb, A. E., Kuderna, L. F., Caulin, A. F., Garcia, J. D., ... & Maley, C. C. (2019). Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an assembly for the humpback whale (Megaptera novaeangliae). Molecular biology and evolution, 36(8), 1746-1763.
Edited by Carlo C. Maley and Mel Greaves
This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention. The book is designed for researchers starting their careers. Each chapter lays out open questions in the field and recommends potential methods to address those questions.
Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
Martinez, P., Mallo, D., Paulson, T. G., Li, X., Sanchez, C. A., Reid, B. J., ... & Maley, C. C. (2018). Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels. Nature communications, 9(1), 794.
Classifying the evolutionary and ecological features of neoplasms
Maley, C. C., Aktipis, A., Graham, T. A., Sottoriva, A., Boddy, A. M., Janiszewska, M., ... & Anderson, K. S. (2017). Classifying the evolutionary and ecological features of neoplasms. Nature Reviews Cancer, 17(10), 605.
Natural selection in cancer biology: from molecular snowflakes to trait hallmarks
Fortunato, A., Boddy, A., Mallo, D., Aktipis, A., Maley, C. C., & Pepper, J. W. (2017). Natural selection in cancer biology: from molecular snowflakes to trait hallmarks. Cold Spring Harbor perspectives in medicine, 7(2), a029652.
Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
Martinez, P., Timmer, M. R., Lau, C. T., Calpe, S., del Carmen Sancho-Serra, M., Straub, D., ... & Naber, A. H. (2016). Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus. Nature communications, 7, 12158.
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
Andor, N., Graham, T. A., Jansen, M., Xia, L. C., Aktipis, C. A., Petritsch, C., ... & Maley, C. C. (2016). Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nature medicine, 22(1), 105.
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans
Abegglen, L. M., Caulin, A. F., Chan, A., Lee, K., Robinson, R., Campbell, M. S., ... & Jensen, S. T. (2015). Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. Jama, 314(17), 1850-1860.
Cancer across the tree of life: cooperation and cheating in multicellularity
Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015). Cancer across the tree of life: cooperation and cheating in multicellularity. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1673), 20140219.
Can oncology recapitulate paleontology? Lessons from species extinctions
Walther, V., Hiley, C. T., Shibata, D., Swanton, C., Turner, P. E., & Maley, C. C. (2015). Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology, 12(5), 273.
Life history trade-offs in cancer evolution
Aktipis, C. A., Boddy, A. M., Gatenby, R. A., Brown, J. S., & Maley, C. C. (2013). Life history trade-offs in cancer evolution. Nature Reviews Cancer, 13(12), 883.
Clonal evolution in cancer
Greaves, M., & Maley, C. C. (2012). Clonal evolution in cancer. Nature, 481(7381), 306.
